A Hypervalent Iodine-Induced Double Annulation Enables a Concise Synthesis of the Pentacyclic Core Structure of the Cortistatins
โ Scribed by Frie, Jessica L.; Jeffrey, Christopher S.; Sorensen, Erik J.
- Book ID
- 120409579
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 643 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1523-7060
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We describe a concise and convergent route to the core matrix of the cortistatin steroidal alkaloids. The salient features of the synthesis are the Snieckus cascade methodology and the Masamune alkylative dearomatization. This chemistry lends itself to a total synthesis of the cortistatins and to th
Hypervalent iodine(III)-induced dimerization of indole derivatives, mitragynine, tetrahydrocarbazole, and N b -carbomethoxytryptamine, was investigated. By applying this procedure, the concise total synthesis of rac-and meso-chimonanthines was accomplished.