𝔖 Bobbio Scriptorium
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A highly stereoselective route to substituted bis-tetrahydrofurans from 1,5-dienes.

✍ Scribed by Roger Amouroux; Gabriel Folefoc; Francine Chastrette; Maurice Chastrette

Book ID
104244019
Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
254 KB
Volume
22
Category
Article
ISSN
0040-4039

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✦ Synopsis

Bis-tetrahydrofurans la and. l&, containing four chiral centers, are obtained with a 90 % iscmeric purity from gerzyl and neryl chlorides in four steps including tx~ stereoselective cyclizations.

πŸ“œ SIMILAR VOLUMES

A Concise Route to Racemic Anatoxin a fr
A Concise Route to Racemic Anatoxin a from Cycloocta-1,5-diene
✍ Tse-Lok Ho; Elvira Zinurova πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 German βš– 64 KB

The synthesis of racemic anatoxin a (1a) from cycloocta-1,5-diene via its 1 : 1 cycloadduct with Nchlorosulfonyl isocyanate is described. The N-unsubstituted b-lactam 2b was converted to a b-amino ester 3 which was then submitted to a Pd-catalyzed cyclization to afford the conjugated ester 4a. The N