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A highly efficient methodology for 5-methyl-3-aryl-2-thiooxazolidin-4-ones using lithium perchlorate in DIPEA mediated synthesis

✍ Scribed by Gopal L. Khatik; Anang Pal; Tushar D. Apsunde; Vipin A. Nair

Book ID: 102343081
Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 139 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.369

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✦ Synopsis

Abstract

magnified image An efficient methodology for the synthesis of 5‐methyl‐3‐aryl‐2‐thiooxazolidin‐4‐ones from aryl isothiocyanates has been developed. Aryl isothiocyanates, synthesized from various anilines, were converted to the desired compounds by treating with ethyl lactate in presence of DIPEA and catalytic amount of lithium perchlorate. This method provides a convenient and cost‐effective strategy, with no specific purification protocol. J. Heterocyclic Chem., (2010).

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✍ Gopal L. Khatik; Anang Pal; Tushar D. Apsunde; Vipin A. Nair 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 21 KB

## Abstract Aryl isothiocyanates (III) are converted to the title compounds (V) by treating with ethyl lactate (IV) in the presence of a base and a catalytic amount of lithium perchlorate.