Total synthesis of (±)-7-deoxydaunomycin
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Robert D. Gleim; Steven Trenbeath; R.S.D. Mittal; Charles J. Sih
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Article
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1976
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Elsevier Science
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French
⚖ 230 KB
The anthracycline antibiotics, Daunorubicin', 1 and Adriamycin", 2 are established antineoplastic agents used for the clinical treatment of a broad spectrum of human cancers. The lack of an efficient biosynthetic process' coupled with their therapeutic importance have prompted the investigations of