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A high throughput colorimetric cell proliferation assay for the identification of human cytomegalovirus inhibitors

โœ Scribed by Jean Bedard; Suzanne May; Dominique Barbeau; Leonard Yuen; Robert F Rando; Terry L Bowlin

Book ID
114145195
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
125 KB
Volume
41
Category
Article
ISSN
0166-3542

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Herpes simplex virus type 1 (HSV-1) encodes a deoxyribonuclease that is frequently referred to as alkaline nuclease (AN) because of its elevated pH optimum. Studies with recombinant viruses which contain deletions in the HSV-1 gene encoding AN have indicated that this enzyme is required for efficien