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A high-performance liquid chromatography–tandem mass spectrometric method for the determination of pharmacokinetics of ganaxolone in rat, monkey, dog and human plasma

✍ Scribed by Kumar Ramu; Gilbert N Lam; Ben Chien

Book ID
108447666
Publisher
Elsevier Science
Year
2001
Weight
186 KB
Volume
751
Category
Article
ISSN
0378-4347

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## Abstract A rapid LC‐MS/MS method for quantification of an enaminone analog, E121 in mouse plasma using E118 as an internal standard (IS) has been developed and validated. The analyte was analyzed on C~18~ column using a mobile phase of acetonitrile/methanol/ammonium acetate/formic acid (60:20:20