A heuristic approach to fed-batch optimisation of streptokinase fermentation

✍ Scribed by P. R. Patnaik

• Book ID: 104768672
• Publisher: Springer
• Year: 1995
• Tongue: English
• Weight: 410 KB
• Volume: 13
• Category: Article
• ISSN: 1615-7605
• DOI: 10.1007/bf00420437

✦ Synopsis

Previous studies have shown that the rate of formation of streptokinase, a secondary metabolite, in batch fermentation is proportional to the specific growth rate of the biomass, which in turn is inhibited by its substrate and the primary product (lactic acid). These kinetics suggest the suitability of fed-batch operation to increase the yield of streptokinase. A near-optimal feed policy has been calculated by the chemotaxis algorithm, and it shows a substrate feed rate decreasing nonlinearly and vanishing after 11 hours. This is followed by batch fermentation for a further 8 hours, at the end of which 12% more streptokinase is generated than by purely batch fermentation. Further improvements in productivity are possible.