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A HCO3-umbrella protects human cholangiocytes against bile salt-induced injury

โœ Scribed by Serge Erlinger


Book ID
119218502
Publisher
Elsevier
Year
2012
Tongue
French
Weight
215 KB
Volume
36
Category
Article
ISSN
2210-7401

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A biliary HCO3โˆ’ umbrella constitutes a p
โœ Simon Hohenester; Lucas Maillette de Buy Wenniger; Coen C. Paulusma; Sandra J. v ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 954 KB

Human cholangiocytes are continuously exposed to millimolar levels of hydrophobic bile salt monomers. We recently hypothesized that an apical biliary HCO ร€ 3 umbrella might prevent the protonation of biliary glycine-conjugated bile salts and uncontrolled cell entry of the corresponding bile acids, a