A green one-pot multicomponent synthesis of 4H-pyrans and polysubstituted aniline derivatives of biological, pharmacological, and optical applications using silica nanoparticles as reusable catalyst
β Scribed by Subhash Banerjee; Alissa Horn; Hari Khatri; Grigoriy Sereda
- Book ID
- 104098949
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 608 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 6βformylβ2,3βdimethoxybenzoic acid and secondary amines (dibenzylβ or benzyl(isopropyl)amine) in the presence of silica nanoparticles (silica NPs, __ca.__ 70β nm) proceeds smoothly at room temperature
## Abstract Multicomponent reaction of oβformylbenzoic acid derivative (I) with secondary amines (III) and isocyanides (II) proceeds smoothly in the presence of silica nanoparticles under neat conditions to give dihydroisoindolone derivatives (IV) in good yields.