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A genetic variant in the promoter region of miR-34b/c is associated with a reduced risk of colorectal cancer

✍ Scribed by Gao, Lin-Bo; Li, Li-Juan; Pan, Xin-Min; Li, Zhao-Hui; Liang, Wei-Bo; Bai, Peng; Zhu, Yin-Hua; Zhang, Lin


Book ID
124090994
Publisher
Walter de Gruyter GmbH & Co. KG
Year
2013
Tongue
English
Weight
193 KB
Volume
394
Category
Article
ISSN
1431-6730

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## Abstract The miR‐34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR‐34 function can impair p53‐mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of __pri‐miR‐34b/c__ (423 bp from th