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A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk

✍ Scribed by Rongxi Yang; Bettina Schlehe; Kari Hemminki; Christian Sutter; Peter Bugert; Barbara Wappenschmidt; Juliane Volkmann; Raymonda Varon; Bernhard H. F. Weber; Dieter Niederacher; Norbert Arnold; Alfons Meindl; Claus R. Bartram; Rita K. Schmutzler; Barbara Burwinkel

Publisher
Springer US
Year
2009
Tongue
English
Weight
222 KB
Volume
121
Category
Article
ISSN
0167-6806

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## Abstract A recent candidate gene association study identified a single nucleotide polymorphism (SNP) in the __PPP2R2B__ gene (rs319217, A/G) that manifests allelic differences in the cellular responses to treatment with chemotherapeutic agents (Vazquez et al., Nat Rev Drug Discov 2008;7:979‐87).