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A genetic epidemiologic investigation of breast cancer in families with bilateral breast cancer. II. Linkage analysis

✍ Scribed by Ausa M. Goldstein; Robert W. Haile; M. Anne Spence; Robert S. Sparkes; Annlia Paganini-Hill

Book ID
115089917
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
406 KB
Volume
36
Category
Article
ISSN
0009-9163

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πŸ“œ SIMILAR VOLUMES

Genetic epidemiology of bilateral breast
Genetic epidemiology of bilateral breast cancer: A linkage analysis using the affected-pedigree-member method
✍ Robert W. Haile; Alisa M. Goldstein; Daniel E. Weeks; Robert S. Sparkes; Annlia πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 568 KB

## Abstract We used the affected‐pedigree‐member (APM) method to conduct linkage analyses on 19 pedigrees in which the probands had premenopausal bilateral breast cancer. This method analyzes all affected pairs of relatives, as opposed to siblings only, and incorporates into the analyses informatio

Possible heterogeneity in the segregatio
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We investigated the segregation pattern of breast cancer in families with bilateral breast cancer, classifying families with respect to menopausal status (premenopausal versus postmenopausal) and the interval between diagnosis of the two primary tumors in the probands. Probands were "synchronous" if