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A general synthetic system for 1,2,5-thiadiazoles

โœ Scribed by Leonard M. Weinstock; Paul Davis; Barry Handelsman; Roger Tull


Book ID
104250183
Publisher
Elsevier Science
Year
1966
Tongue
French
Weight
214 KB
Volume
7
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


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In the course of attempts to generate 1,2,5_thiadiasolyne we have encountered an unexpected fragmentation of a 1,2,5_thiadiazole.Diasotisation' of 3-amino-1,2,5_thiadiazole-4-carboxylic acid (I) in the presence of an excess of anthracene yielded none of the anticipated thiazolyne adduct.

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3+2] C-~clnaddifion methodology provides a general and efficient access to 5-alkyl mb~ituted 2(5/-/)furanones. The synthetic approach has been exploited towards the synthesis of naturally oeeurria 8 butenolides.

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## Abstract Title salts **3** were easily obtained by treatment of formimidoyl isothiocyanates **1** with a twofold excess of methanesulfenyl chloride. They showed interesting chemical behavior toward several nitrogen and carbon nucleophiles. Substitution reactions with isothioureas and acetamide i