✍ Scribed by Yong Qiang Tu; Liang Dong Sun
No coin nor oath required. For personal study only.
A general and etticiant approach for synthesis of dihydruagarofuran sesquiterpanoid, the core structure of the polyol esters extensively present in the Celastraceae plants, has beqm developed by a series of transformations, which mainly include three creative and synthetically valuable conversions: the strategic donble-bond shifting of 3, the versatile re~.gement of epoxide 5 gmerating two key functions, the C5-OH and 7,11-Double-bond, and the stereoselective cyclizatiord reduction of 8 constructing the tetrahydrofuran ring of 11. Thus the sesquiterpenoid 3ct,6ct,12lrihydroxy-dihydoagarofuran I was synthesized.
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Vicinal dianions derived from diethyl a-aroylsuccinates were found to react with carbonyl compounds b-regioselectively to afford a-aroyl-g-butyrolactones, which were converted into a-arylidene-g-butyrolactones by reduction with H 2 /Pd-C followed by elimination employing methanesulfonyl chloride in
The photomediated generation of a-hydroxyalkyl radicals from simple acyclic and cyclic alcohols, and acyclic diols, and their subsequent carbon-carbon bond forming reaction with propiolate esters and acetylenedicarboxylates, gives a mixture of a b-(hydroxyalkyl)enoate, the result of a formal cis add