A general synthesis of medium-sized ring amines
✍ Scribed by Manfred G. Reinecke; Louis R. Kray; Robert F. Francis
- Book ID
- 104250017
- Publisher
- Elsevier Science
- Year
- 1965
- Tongue
- French
- Weight
- 178 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract Medium‐sized lactams bearing an axially chiral allene unit have been synthesized by using an aza‐ketene Claisen rearrangement. Starting from 2‐alkynylpiperidines or 2‐alkynylazepines, ring enlargement enabled the highly diastereoselective formation of 10‐ or 11‐membered lactams with a 4
n studies in medium sized ring& are complicated by the flexibility exhibited by these compounds, the presence of a double bond as in cycloheptenes simplifies the system to a flexible boat and a reasonably rigid chair conformation. 3 Azacycloheptene (benzazepine) derivatives have been well described