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A General Solution to the Modular Synthesis of Polyketide Building Blocks by Kanemasa Hydroxy-Directed Nitrile Oxide Cycloadditions

✍ Scribed by Jeffrey W. Bode; Nina Fraefel; Dieter Muri; Erick M. Carreira

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 96 KB
Volume: 40
Category: Article
ISSN: 0044-8249
DOI: 10.1002/1521-3773(20010601)40:11<2082::aid-anie2082>3.0.co;2-1

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✦ Synopsis

A single, convenient reaction protocol and the same set of readily available starting materials suffice for the modular synthesis of all possible polypropionate diastereomers. This general method for the diastereoselective synthesis of syn, anti, and methyl ketone aldol adducts utilizes a powerful Mg -mediated, hydroxy-directed nitrile oxide cycloaddition. The free hydroxy group provides an ideal synthetic handle enabling the rapid assembly of complex polyketide structures. TBS=tBuMe Si.

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ChemInform Abstract: A General Solution

ChemInform Abstract: A General Solution to the Modular Synthesis of Polyketide Building Blocks by Kanemasa Hydroxy-Directed Nitrile Oxide Cycloadditions.

✍ Jeffrey W. Bode; Nina Fraefel; Dieter Muri; Erick M. Carreira 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

A Modular Approach to Polyketide Buildin

A Modular Approach to Polyketide Building Blocks: Cycloadditions of Nitrile Oxides and Homoallylic Alcohols.

✍ Nina Lohse-Fraefel; Erick M. Carreira 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 41 KB 👁 1 views