The bisbenzotriazole compound (I) is a safe, mild, and versatile reagent for the synthesis of unsymmetrical tetrasubstituted ureas of type (Va)-(Ve). It can also be used for the preparation of di-and trisubstituted ureas such as (Vf) and (Vg).
A General Method for the Solid-Phase Synthesis of Unsymmetrical Tri- and Tetrasubstituted Ureas
β Scribed by Zheng, Changsheng; Combs, Andrew P.
- Book ID
- 119961068
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 137 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1520-4766
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Abstrnctr A general method for the solid-phase synthesis of ureas has been developed. The key intermediate being a p-nitrophenylcarbamate which is transformed into the urea by reaction with primary or secondary amines. The products obtained are of high chemical purity. The generation of molecular d
A new method for producing unsymmetrical, tetrasubstituted ureas from N, N'carbonyldiimidazole (CDI) is presented. Carbamoyl imidazolium salts are prepared from the reaction of CDI with a secondary amine, followed by alkylation with MeI. Secondary amines add with ease to imidazolium salts at room te
## Abstract For Abstract see ChemInform Abstract in Full Text.