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A general method for the detection of large GAG repeat expansions by fluorescent PCR

✍ Scribed by Warner, Jon P. (author);Barron, Lilias H. (author);Goudie, David (author);Kelly, Kevin (author);Dow, David (author);Fitzpatrick, David R. (author);Brock, David J.H. (author)


Book ID
118015436
Publisher
BMJ Publishing Group
Year
1996
Tongue
English
Weight
780 KB
Volume
33
Category
Article
ISSN
0022-2593

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Huntington disease (HD) is an autosomal dominant neurodegenerative disorder associated with expansions of an unstable CAG trinucleotide repeat in exon 1 of the IT15 gene. In normal individuals, IT15 contains up to 35 CAG repeats, while in affected the repeat length is >36. Polymerase chain reaction