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A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

✍ Scribed by Spies, Thomas; Bresnahan, Maureen; Bahrain, Seiamak; Arnold, Daniele; Blanck, George; Mellins, Elizabeth; Pious, Donald; DeMars, Robert


Book ID
109766815
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
648 KB
Volume
348
Category
Article
ISSN
0028-0836

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The proteasome is a major enzyme that cleaves proteins for antigen presentation. Cleaved peptides traffic to the cell surface, where they are presented in the context of major histocompatibility complex (MHC) class I. Recognition of these complexes by cytotoxic T lymphocytes is crucial for eliminati