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A ‘gain of function’ mutation in a protein mediates production of novel modified nucleosides

✍ Scribed by Pomerantz, Steven C; Björk, Glenn R; Chen, Peng; Crain, Pamela F; Näsvall, S Joakim

Book ID
110031061
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
241 KB
Volume
24
Category
Article
ISSN
0261-4189

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## background Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders arising from a multipotent progenitor. The loss of heterozygosity (LOH) on the short arm of chromosome 9 (9pLOH) in myeloproliferative disorders suggests that 9p harbors