A G-to-A Substitution at Nucleotide Position 3316 in Mitochondrial DNA Is Associated with Japanese Non-Insulin-Dependent Diabetes Mellitus
β Scribed by Masato Odawara; Kayoko Sasaki; Kamejiro Yamashita
- Book ID
- 115579148
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 186 KB
- Volume
- 227
- Category
- Article
- ISSN
- 0006-291X
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π SIMILAR VOLUMES
The mitochondrial DNA tRNA Leu(UUR) A to G 3243 mutation is associated with maternally inherited diabetes in Caucasians and Japanese. In a Hong Kong Chinese population we have detected the 3243 mutation in 2 of 74 unrelated subjects with well characterized insulin-dependent (Type 1) diabetes mellitu
Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segments under non-denaturing conditions and variants were sequenced. A variant pattern was detec