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A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians

✍ Scribed by K. S. Park; J. C. Chan; L.-M. Chuang; S. Suzuki; E. Araki; K. Nanjo; L. Ji; M. Ng; M. Nishi; H. Furuta; T. Shirotani; B. Y. Ahn; S. S. Chung; H.-K. Min; S. W. Lee; J. H. Kim; Y. M. Cho; H. K. Lee; for The Study Group of Molecular Diabetology in Asia

Publisher
Springer
Year
2008
Tongue
English
Weight
178 KB
Volume
51
Category
Article
ISSN
0012-186X

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Type 2 (non-insulin dependent) diabetes mellitus may be inherited along the maternal line and a variety of mitochondrial DNA (mtDNA) variants have been implicated in the pathogenesis. We have previously reported mutations in five regions of the mitochondrial genome which encompass 11 of the 22 tRNA