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A further study on the effect of physostigmine on memory in rats

โœ Scribed by Grizelda George; Jane Mellanby


Book ID
118861483
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
663 KB
Volume
81
Category
Article
ISSN
0006-8993

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Effects of physostigmine on memory test
โœ C. M. Smith; J. S. Coogan; S. Hart ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer ๐ŸŒ English โš– 296 KB

The effects of an intraveneous infusion of physostigmine (0.94 mg infused over 60 min) on performance in memory tests were studied in 12 young subjects. Drug effects were modest and are discussed in relation to results of physostigmine studies in Alzheimer patients.

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## Abstract Because there is evidence that central cholinergic mechanisms are depleted in dementia, we studied the effects of central cholinergic augmentation on the memory of 5 patients with Alzheimer disease. Patients received placebo, lecithin, physostigmine, or lecithin plus physostigmine in a