Seventeen normal volunteers received either 0.5 mg, 1.5 mg, or 2.5 mg physostigmine i.v. in a placebo-drug-placebo single-blind design. EEG was recorded simultaneously and analyzed by computerized spectral analysis. Eleven healthy elderly volunteers (mean age = 69.1 years) with mild memory impairmen
Choline chloride effects on memory: Correlation with the effects of physostigmine
โ Scribed by Richard C. Mohs; Kenneth L. Davis
- Book ID
- 119094175
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 551 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0165-1781
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The effects of an intraveneous infusion of physostigmine (0.94 mg infused over 60 min) on performance in memory tests were studied in 12 young subjects. Drug effects were modest and are discussed in relation to results of physostigmine studies in Alzheimer patients.
## Abstract Because there is evidence that central cholinergic mechanisms are depleted in dementia, we studied the effects of central cholinergic augmentation on the memory of 5 patients with Alzheimer disease. Patients received placebo, lecithin, physostigmine, or lecithin plus physostigmine in a