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A functionally relevantIRF5haplotype is associated with reduced risk to Wegener’s granulomatosis

✍ Scribed by Stefan Wieczorek; Julia U. Holle; Stephanie Müller; Harald Fricke; Wolfgang L. Gross; Jörg T. Epplen


Publisher
Springer
Year
2010
Tongue
English
Weight
260 KB
Volume
88
Category
Article
ISSN
0946-2716

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## Abstract __p73__, a structural and functional homologue of __p53__, shares some p53‐like tumor suppressor activity but also possesses oncogenic activity. Therefore, __p73__ plays an important role in modulating cell‐cycle control and apoptosis. A potentially functional dinucleotide polymorphism,