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A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis

✍ Scribed by Baugh, J A; Chitnis, S; Donnelly, S C; Monteiro, J; Lin, X; Plant, B J; Wolfe, F; Gregersen, P K; Bucala, R


Book ID
110037399
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
160 KB
Volume
3
Category
Article
ISSN
1466-4879

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## Abstract ## Objective To establish linkage and replicate the association of macrophage migration inhibitory factor (MIF) with juvenile idiopathic arthritis (JIA). ## Methods Three hundred twenty‐one Caucasian simplex families from the UK were genotyped for polymorphisms of MIF using SNaPshot

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Background: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with increased expression in inflammatory bowel disease. The aim of the study was to analyze the role of the MIF -173G/C single nucleotide polymorphism in Crohn's disease (CD). ## Methods: Using restriction fra