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A functional polymorphism in the Eta-1 promoter is associated with allele specific binding to the transcription factor Sp1 and elevated gene expression

✍ Scribed by Tina Hummelshoj; Lars P. Ryder; Hans O. Madsen; Niels Odum; Arne Svejgaard

Book ID: 116755633
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 155 KB
Volume: 43
Category: Article
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2005.05.012

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## Abstract Matrix metalloproteinases (MMPs) play an important role in several steps of cancer development. A single guanine insertion polymorphism (2G) in the __MMP1__ promoter sequence at −1,607 creates an Ets binding site and thus results in enhancing transcriptional activity. This study aimed t