A Common Promoter Variant of TBX21 is Associated with Allele Specific Binding to Yin-Yang 1 and Reduced Gene Expression

Homozygosity for a Common Polymorphism i

Homozygosity for a Common Polymorphism in the Islet-specific Promoter of the Glucokinase Gene is Associated with a Reduced Early Insulin Response to Oral Glucose in Pregnant Women

✍ Zaidi, F.K.; Wareham, N.J.; McCarthy, M.I.; Holdstock, J.; Kalloo-Hosein, H.; Kr 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB 👁 2 views

A commonly occurring sequence variant in the islet-specific promoter of the glucokinase gene (-30 G to A) has been variably reported to be associated with reduced insulin secretory responses to oral glucose. The effect of this promoter variant may be subtle and only become apparent under conditions