A Functional Haplotype of PADI4 Gene in Rheumatoid Arthritis: Positive Correlation in a French Population
β Scribed by GANDJBAKHCH, F.; FAJARDY, I.; FERRE, B.; DUBUCQUOI, S.; FLIPO, R.-M.; ROGER, N.; SOLAU-GERVAIS, E.
- Book ID
- 111672246
- Publisher
- Journal of Rheumatology Publishing Company
- Year
- 2009
- Tongue
- English
- Weight
- 129 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0315-162X
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## Objective: In the era of postgenomic research, linkage- and association-based strategies are beginning to reveal novel complex disease genes. using such an approach, a functional haplotype of the peptidylarginine deiminase 4 gene (padi4) has recently been identified as a gene conferring suscepti
## Abstract ## Objective Recent studies of 2 complex diseases, rheumatoid arthritis (RA) and Crohn's disease (CD), showed associations with genes mapping to the cytokine gene cluster on 5q31. In particular, a functional singleβnucleotide polymorphism (SNP) mapping to intron 1 of the organic cation