A functional haplotype and expression of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Chinese
β Scribed by L. Y. Fan; W. J. Wang; Q. Wang; M. Zong; L. Yang; H. Zhang; L. S. Sun; T. B. Lu; J. Han
- Book ID
- 110892846
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 179 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0001-2815
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## Objective: In the era of postgenomic research, linkage- and association-based strategies are beginning to reveal novel complex disease genes. using such an approach, a functional haplotype of the peptidylarginine deiminase 4 gene (padi4) has recently been identified as a gene conferring suscepti
## Abstract ## Objective Antiβcyclic citrullinated peptide (antiβCCP) antibodies are rheumatoid arthritis (RA)βspecific serologic markers. RA susceptibility has been associated with HLAβDRB1 shared epitope (SE) alleles and singleβnucleotide polymorphism (SNP) haplotypes in the peptidyl arginine de