✦ LIBER ✦

A fluorouridine-anti-CEA immunoconjugate is therapeutically effective in a human colonic cancer xenograft model

✍ Scribed by Lisa B. Shih; Hong Xuan; Robert M. Sharkey; David M. Goldenberg

Publisher: John Wiley and Sons
Year: 1990
Tongue: French
Weight: 744 KB
Volume: 46
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910460625

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

5‐fluorouridine (FUR), an antineoplastic agent, was sitespecifically conjugated to the carbohydrate moiety of a anticarcinoembryonic antigen (CEA) monoclonal antibody (MAb) by using amino‐dextran as the intermediate carrier. The final immunoconjugate contains approximately 30‐35 molecules of FUR per molecule of immunoglobulin, has immunoreactivity retained as examined by flow cytometry, and is cytotoxic to the target cells as examined by ^75^selenomethionine incorporation studies. In the GW‐39/nude mouse model, the conjugate remained efficient in targeting the human colonic tumor and possessed greater inhibitory growth effects on the subcutaneous tumor than free FUR or an irrelevant antibody conjugate. In addition, the reduced host toxicity of the conjugate may permit the use of this agent in a high‐dose therapy of this tumor system.

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