A family with three germline mutations in BRCAl and BRCA2
โ Scribed by Alexander Liede; Kelly Metcalfe; Kenneth Offit; Karen Brown; Shari Miller; Steven A. Narod; Roxana Moslehi
- Book ID
- 110887860
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 354 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0009-9163
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๐ SIMILAR VOLUMES
Germline mutations of BRCA2 were examined in 20 Japanese breast cancer families without BRCA1 mutations, including one demonstrating cancer development in a male. Three different mutations, resulting in truncation of the BRCA2 protein, were detected in 3 different families. They were 9474insA (exon
Germline mutations in the BRCA2 gene have been shown to be associated with familial female and male breast cancer. Mutations occur throughout the entire coding region of the gene, and there is considerable ethnic and geographical diversity in the deleterious mutations detected in different populatio