Sister chromatid exchanges (SCEs) were studied in peripheral human leukocytes from 16 patients with balanced translocations or with unbalanced karyotypes, and from 4 controls. No difference was seen between these two groups of people in the mean number of SCEs per cell, or in the total number of SCE
A family with balanced D1→Cs-translocation carriers and unbalanced offspring
✍ Scribed by G. R. Stalder; E. M. Buhler; G. Gadola; R. Widmer; F. Freuler
- Book ID
- 104751485
- Publisher
- Springer
- Year
- 1964
- Tongue
- English
- Weight
- 366 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0340-6717
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Carriers of the standard translocation t(11;22) (q23.3;q11.2) produce only one type of unbalanced offspring, a tertiary trisomy resulting into the karyotype 47,XX or XY, +der(22)t(11;22)(q23.3;q11.2), usually derived from the mother. The exception is one single patient 47,XY,t(11;22)(q23.3;q11.2), +
## Abstract We report an unusual case of a familial complex chromosome rearrangement (CCR), ascertained through prenatal diagnosis. The fetus carried an apparently balanced CCR with a recombinant 3‐segment chromosome derived from two paternal reciprocal translocations involving both homologs of chr