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A Family of “Click” Nucleosides for Metal-Mediated Base Pairing: Unravelling the Principles of Highly Stabilizing Metal-Mediated Base Pairs

✍ Scribed by Richters, Tim; Krug, Olga; Kösters, Jutta; Hepp, Alexander; Müller, Jens

Book ID
127128227
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
513 KB
Volume
20
Category
Article
ISSN
0947-6539

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Design and synthesis of a new type of modified nucleoside for triple helix-mediated adenine-thymine base pair recognition: Formation of hydrogen bonds to the far-side adenine
✍ Akiko Saito; Reiko Kuroda 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 208 KB

We have synthesized a new class of modified nucleoside, X, that could recognize adenine-thymine base pairs. They were designed to form the triple helix of A-ToX motif, where X forms hydrogen bonds to the N7 and NH2 of the far-side adenine in the major groove. Compounds 1 and 2 are a new type of trip