## Abstract Idiopathic restless legs syndrome (RLS) frequently follows an autosomal dominant inheritance with a variable clinical expressivity of symptoms. We describe the largest German kindred of familial RLS with 20 affected and investigated members in four generations with a variety of clinical
A familial chromosomal syndrome in a large kindred
β Scribed by Stanley Walzer; Blaise Favara; Park S. Gerald
- Book ID
- 118534915
- Publisher
- Elsevier Science
- Year
- 1966
- Tongue
- English
- Weight
- 298 KB
- Volume
- 69
- Category
- Article
- ISSN
- 1097-6833
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More than 40 point mutations (producing different clinical manifestations) have been described in diverse points of the plasma protein transthyretin (TTR). The Met30 is considered the most common mutation, the Tyr77 mutation being the second most prevalent. However, data from patients with this late