✦ LIBER ✦

A FACILE SYNTHETIC ROUTE TO HYDROXY METABOLITES OF TRICYCLIC ANTIDEPRESSANTS

✍ Scribed by Adamczyk, Maciek; Chen, Yon-Yih; Fishpaugh, Jeffrey R.

Book ID: 127283389
Publisher: Taylor and Francis Group
Year: 1991
Tongue: English
Weight: 407 KB
Volume: 23
Category: Article
ISSN: 0030-4948
DOI: 10.1080/00304949109458211

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## Abstract The enantiomers of MK‐196, (6,7‐dichloro‐2‐methyl‐1‐oxo‐2‐phenyl‐5‐indanyloxy)‐acetic acid, and the 2‐(4‐hydroxyphenyl) derivative, the major metabolite of MK‐196, were resolved by classical methods using α‐methylbenzylamine salts, and converted to the corresponding, enantiomerically pu