✦ LIBER ✦
A facile synthetic route to the 14C-labeled enantiomers of MK-196, A new uricosuric diuretic, and its major metabolite
✍ Scribed by Otto W. Woltersdorf Jr.
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- French
- Weight
- 217 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The enantiomers of MK‐196, (6,7‐dichloro‐2‐methyl‐1‐oxo‐2‐phenyl‐5‐indanyloxy)‐acetic acid, and the 2‐(4‐hydroxyphenyl) derivative, the major metabolite of MK‐196, were resolved by classical methods using α‐methylbenzylamine salts, and converted to the corresponding, enantiomerically pure (indanyloxy)acetic acids‐α‐^14^C by facile ether cleavage with pyridine hydrochloride to the 5‐indanols, selective O‐re‐alkylation with methyl bromoacetate‐2‐^14^C and subsequent saponification.