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A facile synthesis of the spiroindoline-based growth hormone secretagogue, MK-677

โœ Scribed by Xian Liang Qi; Er Qun Yang; Jun Tao Zhang; Tao Wang; Xiao Ping Cao


Book ID
113523409
Publisher
Chinese Electronic Periodical Services
Year
2012
Tongue
English
Weight
333 KB
Volume
23
Category
Article
ISSN
1001-8417

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The preparation of the Merck Growth Hormone Secretagogue; MK-677 is described. A Fischer indole/reduction based strategy provides the novel spiroindoline nucleus of this potent compound. This optimized sequence necessitates the isolation of only one intermediate 10 and provides MK-677 in 48% overall