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The effect of treatment with the oral growth hormone (GH) secretagogue MK-677 on GH isoforms

✍ Scribed by J. Svensson; C.L. Boguszewski; F. Shibata; B. Carlsson; L.M.S. Carlsson; B.-Å. Bengtsson


Book ID
117734273
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
118 KB
Volume
13
Category
Article
ISSN
1096-6374

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✍ Peter E. Maligres; Ioannis Houpis; Kai Rossen; Audrey Molina; Jess Sager; Veena 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 706 KB

The preparation of the Merck Growth Hormone Secretagogue; MK-677 is described. A Fischer indole/reduction based strategy provides the novel spiroindoline nucleus of this potent compound. This optimized sequence necessitates the isolation of only one intermediate 10 and provides MK-677 in 48% overall