A fully functionalised synthesis of taxol A-ring, through Michael/Wittig reaction and regioselective opening epoxide as key steps and also a methodology for substituted cyclohexadienes through tandem Michael/WRtig reaction is described.
A facile synthesis of substituted conjugated cyclohexadienes.
โ Scribed by William G. Dauben; David J. Hart; Junes Ipaktschi; Alan P. Kozikowski
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- French
- Weight
- 188 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
We wish to report a general method for the having structure 4. Previous procedures suffer difficulty of execution.
๐ SIMILAR VOLUMES
Two efficient methods were explored for the synthesis of various conjugated exo-glycals: (i) by nucleophilic addition of sugar lactones with a subsequent dehydration, and (ii) by selenylation of C-glycosides with a subsequent selenoxide elimination. These reactions occurred in a stereoselective mann
Taxol Synthesis: Synthesis of A-Ring and a Methodology for Substituted Cyclohexadienes. -Key step in the synthesis of taxol-A ring synthon (IV) is a Michael/Wittig reaction for the construction of the cyclohexadiene skeleton. Further studies concerning this reaction reveal that the method is a gene
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