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A facile synthesis of spiroketals

✍ Scribed by Margaret A. Brimble; David L. Officer; Geoffrey M. Williams


Book ID
103402317
Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
203 KB
Volume
29
Category
Article
ISSN
0040-4039

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A two step synthesis of spiroketals
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Solid-Phase Synthesis of [5.5]-Spiroketa
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## Abstract An efficient and reliable multi‐step synthesis of 251 natural product‐like [5.5]‐spiroketals on solid supports has been developed. As central key step, a double intramolecular hetero‐Michael (DIHMA) reaction to alkynones was applied. The sequence allows for introduction of numerous subs