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A Facile Synthesis of Optically Active β-Amino-β-arylethylphosphonates by Mitsunobu Reaction

✍ Scribed by Chengfu Xu; Chengye Yuan

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
156 KB
Volume
2004
Category
Article
ISSN
1434-193X

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✍ Gmeiner, Peter ;Hummel, Evi ;Haubmann, Christian 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 695 KB

## Abstract Starting from the enantiomerically pure building block 2 which is readily available from D‐asparagine α,β‐disubstituted β‐amino nitriles and β‐amino acids could be synthesized. After deprotonation of the nitrile α‐position the introduction of substituents was performed by alkylation of