A Facile Synthesis of N-Boc-Protected Pyrroles by Cyclodehydration of γ-Amino-α,β-enals and -enones

✍ Scribed by Olivier Paulus; Gilles Alcaraz; Michel Vaultier

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 170 KB
• Volume: 2002
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/1099-0690(200208)2002:15<2565::aid-ejoc2565>3.0.co;2-i

✦ Synopsis

A novel series of N-Boc-substituted and fused pyrroles was prepared by cyclodehydration of readily accessible (E)-γ-(tert-butoxycarbonylamino)-α,β-enals and -enones. Functionalisation of the pyrrole ring was then explored with 2borylated pyrroles in the Suzuki-Miyaura coupling.