A facile synthesis of functionalized catechols

✍ Scribed by Chaozhong Li; Robert J. angelici

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 191 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00793-x

✦ Synopsis

A general route to functionalized catechols is achieved by the reaction of 3,6-di(chloromethyl)-4,5dimethyl-catechol with various nucleophiles in the presence of a base. The reactions are proposed to occur by way of a dehydrochlorinated intermediate which undergoes Michael additions to give the catechol products.