✦ LIBER ✦

A facile synthesis of asterriquinone D

✍ Scribed by Yasuhiro Tanoue; Takashi Motoi; Yutaka Masuda; Norihisa Kai; Kazunori Sakata; Mamoru Hashimoto; Takeshi Nagai

Publisher: Journal of Heterocyclic Chemistry
Year: 2008
Tongue: English
Weight: 229 KB
Volume: 45
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570450544

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✦ Synopsis

Abstract

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Asterriquinone D was easily synthesized in three steps from 2,5‐dichloro‐1,4‐benzoquinone. The reaction of benzoquinone with indole in the presence of Pd(OAc)~2~, followed by oxidation with cerium (IV) ammonium nitrate (CAN) produced 3,6‐dichloro‐2,5‐bis (3‐indolyl)‐1,4‐benzoquinone. The methoxylation of the dichloride with NaOH in CH~3~OH afforded asterriquinone D.

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