✦ LIBER ✦

A facile synthesis of 2-substituted indoles from (2-aminobenzyl)triphenylphosphonium salts

✍ Scribed by Shin'ichi Taira; Hiroshi Danjo; Tsuneo Imamoto

Book ID: 104250882
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 95 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00460-4

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✦ Synopsis

A variety of 2-substituted 1-acylindoles were obtained in yields ranging from 40 to 94% by intramolecular Wittig reaction employing (2-aminobenzyl)triphenylphosphonium derivatives and acid anhydride in the presence of triethylamine. The reaction of (2-aminobenzyl)phosphonium derivatives with various acyl chlorides in 2,6-lutidine also proceeded to give the corresponding indoles in 28-67% yields.

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