A facile synthesis of 1-alkyl-5-arylalkoxy-6-methoxy-3,4-dihydroisoquinolines
✍ Scribed by Heong-Seup Yim; Ho-Kyun Kim; Jeum-Jong Kim; Deok-Heon Kweon; Yong-Jin Yoon; Sang-Gyeong Lee; Jung-Ho Kim
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 325 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
magnified image
1‐Alkyl‐5‐arylalkoxy‐6‐methoxy‐3,4‐dihydroisoquinolines were synthesized by the alkylation of 1‐alkyl‐5‐hydroxy‐6‐methoxy‐3,4‐dihydroisoquinolines with arylalkyl halide in the presence of potassium carbonate. 1‐Alkyl‐5‐hydroxy‐6‐methoxy‐3,4‐dihydroisoquinolines as key precursor prepared from o‐vaniline via 6 steps.
📜 SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract For Abstract see ChemInform Abstract in Full Text.
In an attempt to ascertain the scope of using ethyl polyphosphate in the Bischler-Napieralsky annelation reaction, a title compound was synthesized and reduced to the respective 1-(3,4-dimethoxyphenylmethyl)-3-phenyl-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline.