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A facile synthesis of 1-alkyl-5-arylalkoxy-6-methoxy-3,4-dihydroisoquinolines

✍ Scribed by Heong-Seup Yim; Ho-Kyun Kim; Jeum-Jong Kim; Deok-Heon Kweon; Yong-Jin Yoon; Sang-Gyeong Lee; Jung-Ho Kim


Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
325 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

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1‐Alkyl‐5‐arylalkoxy‐6‐methoxy‐3,4‐dihydroisoquinolines were synthesized by the alkylation of 1‐alkyl‐5‐hydroxy‐6‐methoxy‐3,4‐dihydroisoquinolines with arylalkyl halide in the presence of potassium carbonate. 1‐Alkyl‐5‐hydroxy‐6‐methoxy‐3,4‐dihydroisoquinolines as key precursor prepared from o‐vaniline via 6 steps.


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Synthesis of 1-(3,4-dimethoxyphenylmethy
✍ Adriana F. Ibañez 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 46 KB

In an attempt to ascertain the scope of using ethyl polyphosphate in the Bischler-Napieralsky annelation reaction, a title compound was synthesized and reduced to the respective 1-(3,4-dimethoxyphenylmethyl)-3-phenyl-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline.