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Synthesis of 1-(3,4-dimethoxyphenylmethyl)-3-phenyl-6,7,8-trimethoxy-3,4-dihydroisoquinoline

✍ Scribed by Adriana F. Ibañez

Publisher
Journal of Heterocyclic Chemistry
Year
2005
Tongue
English
Weight
46 KB
Volume
42
Category
Article
ISSN
0022-152X

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✦ Synopsis

In an attempt to ascertain the scope of using ethyl polyphosphate in the Bischler-Napieralsky annelation reaction, a title compound was synthesized and reduced to the respective 1-(3,4-dimethoxyphenylmethyl)-3-phenyl-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline.

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Preparation of 7,8-dimethoxy-3,4-dihydro
Preparation of 7,8-dimethoxy-3,4-dihydroisoquinoline, facile route to 7,8-dioxygenated-3,4-dihydroisoquinolines
✍ A. M. El-Fishawy; D. J. Slatkin; J. E. Knapp; P. L. Schiff Jr. 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 264 KB

Oxidation of 7,8-dimethoxy-l,2,3,4-tetrahydroisquinoline with potassium permanganate in acetone afforded 7,8-dimethoxy-3,4-dihydroisoquinoline as the primary product. Hence, oxidation of the appropriate secondary nonphenolic 7,8-dioxygenated tetrahydroisoquinoline alkaloid is thus a facile method fo