A facile, scalable preparation of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carbonitriles
✍ Scribed by L. Nathan Tumey; Niala Bhagirath; Biqi Wu; Diane H. Boschelli
- Book ID
- 108285217
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 161 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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## Abstract A facile synthesis of __trans__ isomers of 4‐aryl‐3‐methyl‐6‐oxo‐4,5,6,7‐tetrahydro**‐**2__H__**‐**pyrazolo[3,4‐__b__]pyridine‐5‐carbonitriles via three‐component condensation reaction of an aldehyde, 3‐amino‐5‐methylpyrazole and ethyl cyanoacetate in acetonitrile has been developed und
The title compound, C 20 H 15 FN 4 O, was synthesized by the reaction of 5-amino-3-methyl-1-phenylpyrazole with ethyl 2cyano-3-(4-fluorophenyl)-1-acylate in glycol under microwave irradiation. The tetrahydropyridine ring adopts a distorted envelope conformation. The pyrazole ring forms a dihedral an