A facile procedure for the synthesis of α,β-unsaturated aldehydes by three carbon homologation
✍ Scribed by Stephen F. Martin; Philip J. Garrison
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- French
- Weight
- 206 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
l'he synthesis of (z, &unsaturated aldehydes has been a focus of current interest'. However there are only few methods for the syntheses of a, B-unsaturated aldehydes hy one-carbon homclogation'. We wish to report a convenient synthesis of the 1-alkenecarboxaldehydes from the corresponding carbonyl
Treatment of esters with diisobutylaluminum hydride (DIBAL) in the presence of lithio-trialkylphosphonoacetate results in improved yields of the homologated a,B-unsaturated esters. The problematic overreduction, which has previously observed in the half reduction of esters using DIBAL, is minimal (~